Inhibitory effect of Dillenia indica L. bark extract on testosterone induced benign prostatic hyperplasia in rat
Luk Bahadur Chetry, Hirendra Nath Sarma and Manuj K Bharali
Benign prostatic hyperplasia (BPH) is a common urological disorder of elderly men, which is characterized by hyperplasia of prostatic stromal and epithelial cells. The present study was designed to investigate the inhibitory effect of the Aqueous Bark Extract of Dillenia indica L. (ABEDI) in the BPH rat model. The male rats were treated either corn oil or testosterone (10 mg/kg) dissolved in corn oil and testosterone with ABEDI (100 and 500 mg/kg) consecutively for three weeks. The inhibitory effect of ABEDI on BPH was illustrated by prostate weight, prostatic index, prostate epithelial height, percentage of inhibition and histological examinations. ABEDI caused significant reduction in the prostate weight and prostatic index compared to testosterone induced BPH model group. Serum ALT and creatinine levels did not differ among different experimental groups, when compared with a positive control group. ABEDI treated group also ameliorated the hyperplasia of prostate epithelium in a similar manner as observed in the finasteride (5 mg/kg) treated group. This study indicates that ABEDI significantly reduced the progression of BPH and it may be another phytotherapeutial source of drugs in BPH treatment.
KEYWORDS: Dillenia indica L., BPH, bark extract, testosterone, and rat.